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SGEF Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96DR7
Clone Names 100416053
Peptide ID 100416053
Additional Information
Gene ID 26084
Other Names Rho guanine nucleotide exchange factor 26, SH3 domain-containing guanine exchange factor, ARHGEF26, SGEF
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13325c was selected from the Center region of SGEF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGEF26
Synonyms SGEF
Function Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
Cellular Location Cell projection, ruffle
Tissue Location Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver
Research Areas
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Background

SGEF activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

References

Yamada, S., et al. Oncogene 23(35):5901-5911(2004)Ellerbroek, S.M., et al. Mol. Biol. Cell 15(7):3309-3319(2004)Qi, H., et al. Endocrinology 144(5):1742-1752(2003)

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$ 80.00
Cat# BP13325c
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