|Other Names||Mimitin, mitochondrial, B172-like, B172L, Myc-induced mitochondrial protein, MMTN, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2, NDUFA12-like protein, NDUFAF2, NDUFA12L|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13341c was selected from the Center region of NDUFAF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371).|
|Tissue Location||Highly expressed in ESCC cells. Also expressed in heart, skeletal muscle, liver, and in fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
NADH:ubiquinone oxidoreductase (complex I) catalyzes thetransfer of electrons from NADH to ubiquinone (coenzyme Q) in thefirst step of the mitochondrial respiratory chain, resulting in thetranslocation of protons across the inner mitochondrial membrane.This gene encodes a complex I assembly factor. Mutations in thisgene cause progressive encephalopathy resulting from mitochondrialcomplex I deficiency.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lesch, K.P., et al. Mol. Psychiatry (2010) In press :Herzer, M., et al. Neuropediatrics 41(1):30-34(2010)Hoefs, S.J., et al. Hum. Mutat. 30 (7), E728-E736 (2009) :Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
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