|Other Names||Protein kintoun, Dynein assembly factor 2, axonemal, DNAAF2, C14orf104, KTU|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13345a was selected from the N-term region of C14orf104. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.|
|Cellular Location||Cytoplasm. Note=Localizes in the apical cytoplasm around the gamma-tubulin- positive pericentriolar region, not in the cilia|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a highly conserved protein involved inthe preassembly of dynein arm complexes which power cilia. Thesecomplexes are found in some cilia and are assembled in thecytoplasm prior to transport for cilia formation. Mutations in thisgene have been associated with primary ciliary dyskinesia. Multipletranscript variants encoding different isoforms have been found forthis gene.
Omran, H., et al. Nature 456(7222):611-616(2008)Heilig, R., et al. Nature 421(6923):601-607(2003)
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