|Other Names||Phosducin-like protein 3, HTPHLP, PhPL3, Viral IAP-associated factor 1, VIAF-1, PDCL3, PhLP2A, VIAF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13347a was selected from the N-term region of PDCL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination.|
|Tissue Location||Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the phosducin-like proteinfamily and is a putative modulator of heterotrimeric G proteins.The protein shares extensive amino acid sequence homology withphosducin. Members of the phosducin-like protein family have beenshown to bind to the beta-gamma subunits of G proteins. [providedby RefSeq].
Stirling, P.C., et al. Mol. Biol. Cell 18(6):2336-2345(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Wilkinson, J.C., et al. J. Biol. Chem. 279(49):51091-51099(2004)Lopez, P., et al. J. Biol. Chem. 278(3):1751-1757(2003)
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