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PNPLA1 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N8W4
Clone Names 100416252
Peptide ID 100416252
Additional Information
Gene ID 285848
Other Names Patatin-like phospholipase domain-containing protein 1, 311-, PNPLA1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13348a was selected from the N-term region of PNPLA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PNPLA1
Function Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism.
Cellular Location Cytoplasm. Note=Clearly distributed in the cytoplasm of keratinocytes
Tissue Location Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in the region of keratin filament bundles, which is more pronounced in upper epidermal layers and in the lower cornified layers.
Research Areas
Citations (0)

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Background

Human patatin-like phospholipases, such as PNPLA1, havebeen implicated in regulation of adipocyte differentiation and havebeen induced by metabolic stimuli (Wilson et al., 2006 [PubMed16799181]).

References

Kienesberger, P.C., et al. J. Lipid Res. 50 SUPPL, S63-S68 (2009) :Johansson, L.E., et al. PLoS ONE 4 (4), E5327 (2009) :De Chaudhuri, S., et al. Environ. Health Perspect. 116(4):501-505(2008)Wilson, P.A., et al. J. Lipid Res. 47(9):1940-1949(2006)

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$ 80.00
Cat# BP13348a
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