|Other Names||Otospiralin, OTOS, OTOSP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13350a was selected from the N-term region of OTOS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be essential for the survival of the neurosensory epithelium of the inner ear.|
|Tissue Location||Ear specific.|
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Provided below are standard protocols that you may find useful for product applications.
Otospiralin is synthesized by nonsensory cells(fibrocytes) of the inner ear, and downregulation of otospiralin inguinea pigs leads to deafness (Lavigne-Rebillard et al., 2003[PubMed 12687421]).
Potkin, S.G., et al. Schizophr Bull 35(1):96-108(2009)Lavigne-Rebillard, M., et al. Neurogenetics 4(3):137-140(2003)Delprat, B., et al. J. Neurosci. 22(5):1718-1725(2002)
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