|Other Names||Protein APCDD1, Adenomatosis polyposis coli down-regulated 1 protein, APCDD1 (HGNC:15718)|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13356a was selected from the N-term region of APCDD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This locus encodes an inhibitor of the Wnt signalingpathway. Mutations at this locus have been associated withhereditary hypotrichosis simplex. Increased expression of this genemay also be associated with colorectal carcinogenesis.
Shimomura, Y., et al. Nature 464(7291):1043-1047(2010)Takahashi, M., et al. Cancer Res. 62(20):5651-5656(2002)
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