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APCDD1 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8J025
Clone Names 100416296
Peptide ID 100416296
Additional Information
Gene ID 147495
Other Names Protein APCDD1, Adenomatosis polyposis coli down-regulated 1 protein, APCDD1 (HGNC:15718)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13356a was selected from the N-term region of APCDD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name APCDD1 (HGNC:15718)
Function Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
Research Areas
Citations (0)

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Background

This locus encodes an inhibitor of the Wnt signalingpathway. Mutations at this locus have been associated withhereditary hypotrichosis simplex. Increased expression of this genemay also be associated with colorectal carcinogenesis.

References

Shimomura, Y., et al. Nature 464(7291):1043-1047(2010)Takahashi, M., et al. Cancer Res. 62(20):5651-5656(2002)

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$ 80.00
Cat# BP13356a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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