|Other Names||Dihydrofolate reductase, mitochondrial, Dihydrofolate reductase-like protein 1, DHFRL1, DHFRP4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13364c was selected from the Center region of DHFRL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.|
|Cellular Location||Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane|
|Tissue Location||Expressed in numerous cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
DHFRL1 may play a role in folate metabolism (Potential).
Semmler, A., et al. J. Neurosurg. 108(5):999-1004(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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