|Other Names||C-type lectin domain family 7 member A, Beta-glucan receptor, C-type lectin superfamily member 12, Dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, Dectin-1, CLEC7A, BGR, CLECSF12, DECTIN1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13369a was selected from the N-term region of CLEC7A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BGR, CLECSF12, DECTIN1|
|Function||Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).|
|Cellular Location||Cell membrane; Single- pass type II membrane protein Isoform 6: Cytoplasm.|
|Tissue Location||Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the C-type lectin/C-typelectin-like domain (CTL/CTLD) superfamily. The encoded glycoproteinis a small type II membrane receptor with an extracellular C-typelectin-like domain fold and a cytoplasmic domain with animmunoreceptor tyrosine-based activation motif. It functions as apattern-recognition receptor that recognizes a variety ofbeta-1,3-linked and beta-1,6-linked glucans from fungi and plants,and in this way plays a role in innate immune response. Alternatetranscriptional splice variants, encoding different isoforms, havebeen characterized. This gene is closely linked to other CTL/CTLDsuperfamily members on chromosome 12p13 in the natural killer genecomplex region.
de Koning, H.D., et al. J. Invest. Dermatol. 130(11):2611-2620(2010)Plantinga, T.S., et al. J. Acquir. Immune Defic. Syndr. 55(1):87-94(2010)Cunha, C., et al. Blood (2010) In press :van der Velden, W.J., et al. Clin. Immunol. 136(2):302-306(2010)Kankkunen, P., et al. J. Immunol. 184(11):6335-6342(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.