|Other Names||Interleukin-1 receptor-like 2, IL-36 receptor, IL-36R, Interleukin-1 receptor-related protein 2, IL-1Rrp2, IL1R-rp2, IL1RL2, IL1RRP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13370c was selected from the Center region of IL1RL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte- derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theinterleukin 1 receptor family. An experiment with transient geneexpression demonstrated that this receptor was incapable of bindingto interleukin 1 alpha and interleukin 1 beta with high affinity.This gene and four other interleukin 1 receptor family genes,including interleukin 1 receptor, type I (IL1R1), interleukin 1receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1),and interleukin 18 receptor 1 (IL18R1), form a cytokine receptorgene cluster in a region mapped to chromosome 2q12. [provided byRefSeq].
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Nakki, A., et al. BMC Med. Genet. 11 (1), 50 (2010) :Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Solovieva, S., et al. J. Rheumatol. 36(9):1977-1986(2009)
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