|Other Names||Uracil phosphoribosyltransferase homolog, UPRT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13372b was selected from the C-term region of UPRT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes uracil phosphoribosyltransferase, whichcatalyzes the conversion of uracil and5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP).This reaction is an important part of nucleotide metabolism,specifically the pyrimidine salvage pathway. The enzyme localizesto the nucleus and cytoplasm. The protein is a potential target forrational design of drugs to treat parasitic infections and cancer.
Zhao, F.J., et al. Prostate Cancer Prostatic Dis. 12(2):166-171(2009)Li, J., et al. J. Hum. Genet. 52(5):415-422(2007)
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