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HS3ST1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O14792
Clone Names 100405062
Additional Information
Gene ID 9957
Other Names Heparan sulfate glucosamine 3-O-sulfotransferase 1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1, 3-OST-1, Heparan sulfate 3-O-sulfotransferase 1, h3-OST-1, HS3ST1, 3OST, 3OST1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13378b was selected from the C-term region of HS3ST1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HS3ST1
Synonyms 3OST, 3OST1
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:9346953, PubMed:8900198, PubMed:9988768). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:8900198, PubMed:9988768). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:8900198, PubMed:9988768).
Cellular Location Golgi apparatus lumen.
Tissue Location Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta
Research Areas
Citations (0)
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Background

Heparan sulfate biosynthetic enzymes are key components ingenerating a myriad of distinct heparan sulfate fine structuresthat carry out multiple biologic activities. The enzyme encoded bythis gene is a member of the heparan sulfate biosynthetic enzymefamily. It possesses both heparan sulfate glucosaminyl3-O-sulfotransferase activity, anticoagulant heparan sulfateconversion activity, and is a rate limiting enzyme for synthesis ofanticoagulant heparan. This enzyme is an intraluminal Golgiresident protein.

References

Lamesch, P., et al. Genomics 89(3):307-315(2007)Edavettal, S.C., et al. Biochemistry 43(16):4680-4688(2004)Hernaiz, M., et al. Biochem. Biophys. Res. Commun. 276(1):292-297(2000)Liu, J., et al. J. Biol. Chem. 274(8):5185-5192(1999)Shworak, N.W., et al. J. Biol. Chem. 274(8):5170-5184(1999)

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$ 277.78
Cat# BP13378b
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