|Other Names||Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2, CACNA2D2, KIAA0558|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13380c was selected from the Center region of CACNA2D2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Note=Colocalizes with CACNA1A in lipid raft fractions.|
|Tissue Location||Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the alpha-2/delta subunitfamily, a protein in the voltage-dependent calcium channel complex.Calcium channels mediate the influx of calcium ions into the cellupon membrane polarization and consist of a complex of alpha-1,alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Variousversions of each of these subunits exist, either expressed fromsimilar genes or the result of alternative splicing. Research on ahighly similar protein in rabbit suggests the protein described inthis record is cleaved into alpha-2 and delta subunits. Alternatetranscriptional splice variants of this gene, encoding differentisoforms, have been characterized.
Donato, R., et al. J. Neurosci. 26(48):12576-12586(2006)Ivanov, S.V., et al. Am. J. Pathol. 165(3):1007-1018(2004)Carboni, G.L., et al. Oncogene 22(4):615-626(2003)Honorio, S., et al. Mol. Cell. Probes 15(6):391-393(2001)Angeloni, D., et al. Mol. Cell. Probes 15(2):125-127(2001)
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