PTAFR Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P25105 |
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Clone Names | 100311191 |
Gene ID | 5724 |
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Other Names | Platelet-activating factor receptor, PAF-R, PAFr, PTAFR, PAFR |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13382b was selected from the C-term region of PTAFR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PTAFR |
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Synonyms | PAFR |
Function | Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PTAFR shows structural characteristics of the rhodopsin(MIM 180380) gene family and binds platelet-activating factor(PAF). PAF is a phospholipid(1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has beenimplicated as a mediator in diverse pathologic processes, such asallergy, asthma, septic shock, arterial thrombosis, andinflammatory processes.
References
Balestrieri, M.L., et al. Biochim. Biophys. Acta 1801(10):1123-1132(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kajiwara, N., et al. J. Allergy Clin. Immunol. 125(5):1137-1145(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Keely, S., et al. Mol. Biol. Cell 21(4):538-546(2010)
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