|Other Names||Platelet-activating factor receptor, PAF-R, PAFr, PTAFR, PAFR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13382b was selected from the C-term region of PTAFR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.|
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Provided below are standard protocols that you may find useful for product applications.
PTAFR shows structural characteristics of the rhodopsin(MIM 180380) gene family and binds platelet-activating factor(PAF). PAF is a phospholipid(1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has beenimplicated as a mediator in diverse pathologic processes, such asallergy, asthma, septic shock, arterial thrombosis, andinflammatory processes.
Balestrieri, M.L., et al. Biochim. Biophys. Acta 1801(10):1123-1132(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kajiwara, N., et al. J. Allergy Clin. Immunol. 125(5):1137-1145(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Keely, S., et al. Mol. Biol. Cell 21(4):538-546(2010)
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