|Other Names||Thioredoxin, mitochondrial, MTRX, Mt-Trx, Thioredoxin-2, TXN2, TRX2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1338a was selected from the N-term region of human Trx2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity.|
|Tissue Location||Widely expressed in adult (at protein level) and fetal tissues.|
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Provided below are standard protocols that you may find useful for product applications.
TRX2 is a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
J. Biol. Chem. 277 (36), 33249-33257 (2002)J. Biol. Chem. 277 (36), 33242-33248 (2002)
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