|Other Names||Josephin-1, Josephin domain-containing protein 1, JOSD1, JSPH1, KIAA0063|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13392b was selected from the C-term region of JOSD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.|
|Cellular Location||Cell membrane. Cytoplasm. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding|
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein remains unknown.
Sakai, N., et al. J. Endocrinol. 198(3):489-497(2008)Albrecht, M., et al. Proteins 50(2):355-370(2003)Dunham, I., et al. Nature 402(6761):489-495(1999)
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