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JOSD1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15040
Clone Names 100406175
Peptide ID 100406175
Additional Information
Gene ID 9929
Other Names Josephin-1, Josephin domain-containing protein 1, JOSD1, JSPH1, KIAA0063
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13392b was selected from the C-term region of JOSD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name JOSD1
Synonyms JSPH1, KIAA0063
Function Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.
Cellular Location Cell membrane. Cytoplasm. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding
Research Areas
Citations (0)

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Background

The function of this protein remains unknown.

References

Sakai, N., et al. J. Endocrinol. 198(3):489-497(2008)Albrecht, M., et al. Proteins 50(2):355-370(2003)Dunham, I., et al. Nature 402(6761):489-495(1999)

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$ 80.00
Cat# BP13392b
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