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AMIGO2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86SJ2
Clone Names 100406230
Peptide ID 100406230
Additional Information
Gene ID 347902
Other Names Amphoterin-induced protein 2, AMIGO-2, Alivin-1, Differentially expressed in gastric adenocarcinomas, DEGA, AMIGO2 {ECO:0000312|EMBL:AAH475951}
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13394b was selected from the C-term region of AMIGO2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMIGO2 {ECO:0000312|EMBL:AAH47595.1}
Function Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Cellular Location Cell membrane; Single-pass type I membrane protein. Nucleus Note=Associated with nucleus as well as plasma membrane Restricted to somata of cerebellar as well as hippocampal neurons (By similarity).
Tissue Location Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
Research Areas
Citations (0)

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Background

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

References

Rabenau, K.E., et al. Oncogene 23(29):5056-5067(2004)Ono, T., et al. J. Neurosci. 23(13):5887-5896(2003)Kuja-Panula, J., et al. J. Cell Biol. 160(6):963-973(2003)

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$ 80.00
Cat# BP13394b
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