AMIGO2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86SJ2 |
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Clone Names | 100406230 |
Gene ID | 347902 |
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Other Names | Amphoterin-induced protein 2, AMIGO-2, Alivin-1, Differentially expressed in gastric adenocarcinomas, DEGA, AMIGO2 {ECO:0000312|EMBL:AAH475951} |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13394b was selected from the C-term region of AMIGO2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AMIGO2 {ECO:0000312|EMBL:AAH47595.1} |
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Function | Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity) |
Tissue Location | Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
References
Rabenau, K.E., et al. Oncogene 23(29):5056-5067(2004)Ono, T., et al. J. Neurosci. 23(13):5887-5896(2003)Kuja-Panula, J., et al. J. Cell Biol. 160(6):963-973(2003)
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