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TAF8 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7Z7C8 |
|---|---|
| Clone Names | 110111025 |
| Gene ID | 129685 |
|---|---|
| Other Names | Transcription initiation factor TFIID subunit 8, Protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, Transcription initiation factor TFIID 43 kDa subunit, TAFII-43, TAFII43, hTAFII43, TAF8, TAFII43, TBN |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13397c was selected from the Center region of TAF8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TAF8 |
|---|---|
| Synonyms | TAFII43, TBN |
| Function | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). |
| Cellular Location | Nucleus. Cytoplasm Note=Predominantly nuclear. |
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Background
This gene encodes one of several TATA-binding protein(TBP)-associated factors (TAFs), which are integral subunits of thegeneral transcription factor complex TFIID. TFIID recognizes thecore promoter of many genes and nucleates the assembly of atranscription preinitiation complex containing RNA polymerase IIand other initiation factors. The protein encoded by this genecontains an H4-like histone fold domain, and interacts with severalsubunits of TFIID including TBP and the histone-fold protein TAF10.Alternatively spliced transcript variants have been described, buttheir biological validity has not been determined. [provided byRefSeq].
References
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Soutoglou, E., et al. Mol. Cell. Biol. 25(10):4092-4104(2005)Guermah, M., et al. Mol. Cell 12(4):991-1001(2003)
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