|Other Names||Transcription initiation factor TFIID subunit 8, Protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, Transcription initiation factor TFIID 43 kDa subunit, TAFII-43, TAFII43, hTAFII43, TAF8, TAFII43, TBN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13397c was selected from the Center region of TAF8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of several TATA-binding protein(TBP)-associated factors (TAFs), which are integral subunits of thegeneral transcription factor complex TFIID. TFIID recognizes thecore promoter of many genes and nucleates the assembly of atranscription preinitiation complex containing RNA polymerase IIand other initiation factors. The protein encoded by this genecontains an H4-like histone fold domain, and interacts with severalsubunits of TFIID including TBP and the histone-fold protein TAF10.Alternatively spliced transcript variants have been described, buttheir biological validity has not been determined. [provided byRefSeq].
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Soutoglou, E., et al. Mol. Cell. Biol. 25(10):4092-4104(2005)Guermah, M., et al. Mol. Cell 12(4):991-1001(2003)
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