|Other Names||Poly(U)-specific endoribonuclease, 31--, Placental protein 11, PP11, Protein endoU, Uridylate-specific endoribonuclease, ENDOU|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13398a was selected from the N-term region of P11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.|
|Tissue Location||Placental-specific, but also associated with various malignant neoplasms|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with protease activity and isexpressed in the placenta. The protein may be useful as a tumormarker. Multiple alternatively spliced transcript variants havebeen found for this protein.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Laneve, P., et al. J. Biol. Chem. 283(50):34712-34719(2008)Gioia, U., et al. J. Biol. Chem. 280(19):18996-19002(2005)Jenne, D. Biochem. Biophys. Res. Commun. 176(3):1000-1006(1991)Grundmann, U., et al. DNA Cell Biol. 9(4):243-250(1990)
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