P11 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P21128 |
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Clone Names | 100406265 |
Gene ID | 8909 |
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Other Names | Poly(U)-specific endoribonuclease, 31--, Placental protein 11, PP11, Protein endoU, Uridylate-specific endoribonuclease, ENDOU |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13398a was selected from the N-term region of P11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ENDOU |
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Function | Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites. |
Cellular Location | Secreted. |
Tissue Location | Placental-specific, but also associated with various malignant neoplasms |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein with protease activity and isexpressed in the placenta. The protein may be useful as a tumormarker. Multiple alternatively spliced transcript variants havebeen found for this protein.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Laneve, P., et al. J. Biol. Chem. 283(50):34712-34719(2008)Gioia, U., et al. J. Biol. Chem. 280(19):18996-19002(2005)Jenne, D. Biochem. Biophys. Res. Commun. 176(3):1000-1006(1991)Grundmann, U., et al. DNA Cell Biol. 9(4):243-250(1990)
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