|Other Names||60S ribosomal protein L3, HIV-1 TAR RNA-binding protein B, TARBP-B, RPL3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13400c was selected from the Center region of RPL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The L3 protein is a component of the large subunit of cytoplasmic ribosomes.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm|
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Ribosomes, the complexes that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 60S subunit. The protein belongsto the L3P family of ribosomal proteins and it is located in thecytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it hasbeen suggested that the protein contributes to tat-mediatedtransactivation. This gene is co-transcribed with several smallnucleolar RNA genes, which are located in several of this gene'sintrons. Alternate transcriptional splice variants, encodingdifferent isoforms, have been characterized. As is typical forgenes encoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome. [provided byRefSeq].
Russo, A., et al. Biochim. Biophys. Acta 1799 (5-6), 419-428 (2010) :Rikova, K., et al. Cell 131(6):1190-1203(2007)Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Bergqvist, M., et al. Dis. Esophagus 19(1):20-23(2006)
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