|Other Names||Septin-9, MLL septin-like fusion protein MSF-A, MLL septin-like fusion protein, Ovarian/Breast septin, Ov/Br septin, Septin D1, SEPT9, KIAA0991, MSF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13402c was selected from the Center region of 40795. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.|
|Cellular Location||Cytoplasm, cytoskeleton Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria|
|Tissue Location||Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues|
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This gene is a member of the septin family involved incytokinesis and cell cycle control. This gene is a candidate forthe ovarian tumor suppressor gene. Mutations in this gene causehereditary neuralgic amyotrophy, also known as neuritis withbrachial predilection. A chromosomal translocation involving thisgene on chromosome 17 and the MLL gene on chromosome 11 results inacute myelomonocytic leukemia. Multiple alternatively splicedtranscript variants encoding different isoforms have beendescribed.
Saito, H., et al. Cancer Genet. Cytogenet. 201(2):111-115(2010)Amir, S., et al. Mol. Cancer Res. 8(5):643-652(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Santos, J., et al. Cancer Genet. Cytogenet. 197(1):60-64(2010)Tanzer, M., et al. PLoS ONE 5 (2), E9061 (2010) :
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