|Other Names||E3 ubiquitin-protein ligase TRIM38, 632-, RING finger protein 15, Tripartite motif-containing protein 38, Zinc finger protein RoRet, TRIM38, RNF15, RORET|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13405b was selected from the C-term region of TRIM38. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The function of this protein has not beenidentified.
Benyamin, B., et al. Am. J. Hum. Genet. 84(1):60-65(2009)Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)Chen, D., et al. J. Biol. Chem. 277(18):15985-15991(2002)Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)Ruddy, D.A., et al. Genome Res. 7(5):441-456(1997)
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