|Other Names||Kelch-like protein 13, BTB and kelch domain-containing protein 2, KLHL13, BKLHD2, KIAA1309|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13407a was selected from the N-term region of KLHL13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a BTB and kelch domain containingprotein and belongs to the kelch repeat domain containingsuperfamily of proteins. The encoded protein functions as anadaptor protein that complexes with Cullin 3 and other proteins toform the Cullin 3-based E3 ubiquitin-protein ligase complex. Thiscomplex is necessary for proper chromosome segregation andcompletion of cytokinesis. Alternate splicing results in multipletranscript variants.
Sumara, I., et al. Cell Cycle 6(24):3004-3010(2007)Sumara, I., et al. Dev. Cell 12(6):887-900(2007)
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