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DEGS1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15121 |
|---|---|
| Clone Names | 100416139 |
| Gene ID | 8560 |
|---|---|
| Other Names | Sphingolipid delta(4)-desaturase DES1, 114--, Cell migration-inducing gene 15 protein, Degenerative spermatocyte homolog 1, Membrane lipid desaturase, DEGS1, DES1, MLD |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13411a was selected from the N-term region of DEGS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DEGS1 (HGNC:13709) |
|---|---|
| Synonyms | DES1, MLD |
| Function | Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (PubMed:11937514, PubMed:30620337, PubMed:30620338). Catalyzes the equilibrium isomerization of retinols (By similarity). |
| Cellular Location | Mitochondrion membrane. Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the membrane fatty aciddesaturase family which is responsible for inserting double bondsinto specific positions in fatty acids. This protein contains threeHis-containing consensus motifs that are characteristic of a groupof membrane fatty acid desaturases. It is predicted to be amultiple membrane-spanning protein localized to the endoplasmicreticulum. Overexpression of this gene inhibited biosynthesis ofthe EGF receptor, suggesting a possible role of a fatty aciddesaturase in regulating biosynthetic processing of the EGFreceptor.
References
Idkowiak-Baldys, J., et al. Biochem. J. 427(2):265-274(2010)Kraveka, J.M., et al. J. Biol. Chem. 282(23):16718-16728(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Ternes, P., et al. J. Biol. Chem. 277(28):25512-25518(2002)
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