|Other Names||Dual oxidase maturation factor 2, Dual oxidase activator 2, DUOXA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13417b was selected from the C-term region of DUOXA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Specifically expressed in thyroid. Also detected in salivary glands.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an endoplasmic reticulum protein that isnecessary for proper cellular localization and maturation offunctional dual oxidase 2. Mutations in this gene have beenassociated with thyroid dyshormonogenesis 5.
Luxen, S., et al. J. Cell. Sci. 122 (PT 8), 1238-1247 (2009) :Zamproni, I., et al. J. Clin. Endocrinol. Metab. 93(2):605-610(2008)Eriksson, A., et al. BMC Gastroenterol 8, 34 (2008) :Grasberger, H., et al. Mol. Endocrinol. 21(6):1408-1421(2007)Grasberger, H., et al. J. Biol. Chem. 281(27):18269-18272(2006)
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