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NLRP5 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P59047 |
|---|---|
| Clone Names | 100416260 |
| Gene ID | 126206 |
|---|---|
| Other Names | NACHT, LRR and PYD domains-containing protein 5, Mater protein homolog, NLRP5, MATER, NALP5 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13418b was selected from the C-term region of NLRP5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NLRP5 |
|---|---|
| Synonyms | MATER {ECO:0000303|PubMed:19542546}, NAL |
| Function | As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER localization (By similarity). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, Cortical granule. Mitochondrion. Nucleus, nucleolus. Cytoplasm. Golgi apparatus |
| Tissue Location | Expressed in cumulus cells (at protein level) (PubMed:19542546). Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as the liver and spinal cord (PubMed:11925379, PubMed:30877238) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the NALPprotein family. Members of the NALP protein family typicallycontain a NACHT domain, a NACHT-associated domain (NAD), aC-terminal leucine-rich repeat (LRR) region, and an N-terminalpyrin domain (PYD). Expression of this gene is restricted to theoocyte. A mouse gene that encodes a maternal oocyte protein,similar to this encoded protein, is required for normal earlyembryogenesis.
References
Cummings, J.R., et al. Tissue Antigens (2010) In press :Rose, J. Phd, et al. Mol. Med. (2010) In press :Maraldi, T., et al. Mol. Hum. Reprod. 15(8):499-506(2009)Sena, P., et al. Reprod. Biomed. Online 18(2):226-234(2009)Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)
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