|Other Names||NACHT, LRR and PYD domains-containing protein 5, Mater protein homolog, NLRP5, MATER, NALP5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13418b was selected from the C-term region of NLRP5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.|
|Cellular Location||Mitochondrion. Nucleus, nucleolus. Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the NALPprotein family. Members of the NALP protein family typicallycontain a NACHT domain, a NACHT-associated domain (NAD), aC-terminal leucine-rich repeat (LRR) region, and an N-terminalpyrin domain (PYD). Expression of this gene is restricted to theoocyte. A mouse gene that encodes a maternal oocyte protein,similar to this encoded protein, is required for normal earlyembryogenesis.
Cummings, J.R., et al. Tissue Antigens (2010) In press :Rose, J. Phd, et al. Mol. Med. (2010) In press :Maraldi, T., et al. Mol. Hum. Reprod. 15(8):499-506(2009)Sena, P., et al. Reprod. Biomed. Online 18(2):226-234(2009)Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)
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