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KRT16 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08779 |
|---|---|
| Clone Names | 100427087 |
| Gene ID | 3868 |
|---|---|
| Other Names | Keratin, type I cytoskeletal 16, Cytokeratin-16, CK-16, Keratin-16, K16, KRT16, KRT16A |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13423c was selected from the Center region of KRT16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KRT16 |
|---|---|
| Synonyms | KRT16A |
| Function | Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. |
| Tissue Location | Expressed in the corneal epithelium (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thekeratin gene family. The keratins are intermediate filamentproteins responsible for the structural integrity of epithelialcells and are subdivided into cytokeratins and hair keratins. Mostof the type I cytokeratins consist of acidic proteins which arearranged in pairs of heterotypic keratin chains and are clusteredin a region of chromosome 17q12-q21. This keratin has beencoexpressed with keratin 14 in a number of epithelial tissues,including esophagus, tongue, and hair follicles. Mutations in thisgene are associated with type 1 pachyonychia congenita,non-epidermolytic palmoplantar keratoderma and unilateralpalmoplantar verrucous nevus.
References
Leung, M.C., et al. J. Proteome Res. 9(10):5153-5163(2010)Trost, A., et al. Mech. Ageing Dev. 131(5):346-353(2010)Gruber, R., et al. Br. J. Dermatol. 161(6):1391-1395(2009)Barcelos, A.C., et al. J. Cutan. Pathol. 36(6):647-654(2009)Wu, C., et al. Exp. Dermatol. 17(8):645-652(2008)
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