|Other Names||Keratin, type I cytoskeletal 16, Cytokeratin-16, CK-16, Keratin-16, K16, KRT16, KRT16A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13423c was selected from the Center region of KRT16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.|
|Tissue Location||Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thekeratin gene family. The keratins are intermediate filamentproteins responsible for the structural integrity of epithelialcells and are subdivided into cytokeratins and hair keratins. Mostof the type I cytokeratins consist of acidic proteins which arearranged in pairs of heterotypic keratin chains and are clusteredin a region of chromosome 17q12-q21. This keratin has beencoexpressed with keratin 14 in a number of epithelial tissues,including esophagus, tongue, and hair follicles. Mutations in thisgene are associated with type 1 pachyonychia congenita,non-epidermolytic palmoplantar keratoderma and unilateralpalmoplantar verrucous nevus.
Leung, M.C., et al. J. Proteome Res. 9(10):5153-5163(2010)Trost, A., et al. Mech. Ageing Dev. 131(5):346-353(2010)Gruber, R., et al. Br. J. Dermatol. 161(6):1391-1395(2009)Barcelos, A.C., et al. J. Cutan. Pathol. 36(6):647-654(2009)Wu, C., et al. Exp. Dermatol. 17(8):645-652(2008)
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