|Other Names||Endothelial lipase, Endothelial cell-derived lipase, EDL, EL, LIPG|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13428c was selected from the Center region of LIPG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.|
|Tissue Location||High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene has substantialphospholipase activity and may be involved in lipoproteinmetabolism and vascular biology. This protein is designated amember of the TG lipase family by its sequence and characteristiclid region which provides substrate specificity for enzymes of theTG lipase family.
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)Huang, J., et al. Transl Res 156(1):1-6(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
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