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DPYS Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q14117
Clone Names 90429114
Peptide ID 90429114
Additional Information
Gene ID 1807
Other Names Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13434b was selected from the C-term region of DPYS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
Tissue Location Liver and kidney.
Research Areas
Citations (0)

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Dihydropyrimidinase catalyzes the conversion of5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism.Dihydropyrimidinase is expressed at a high level in liver andkidney as a major 2.5-kb transcript and a minor 3.8-kb transcript.Defects in the DPYS gene are linked to dihydropyrimidinuria.


Kim, H.Y., et al. BMB Rep 43(8):547-553(2010)van Kuilenburg, A.B., et al. Biochim. Biophys. Acta 1802 (7-8), 639-648 (2010) :Fidlerova, J., et al. Cancer Chemother. Pharmacol. 65(4):661-669(2010)Thomas, H.R., et al. Pharmacogenet. Genomics 18(1):25-35(2008)Thomas, H.R., et al. Pharmacogenet. Genomics 17(11):973-987(2007)

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$ 80.00
Cat# BP13434b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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