|Other Names||Ankyrin repeat and sterile alpha motif domain-containing protein 1B, Amyloid-beta protein intracellular domain-associated protein 1, AIDA-1, E2A-PBX1-associated protein, EB-1, ANKS1B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13437c was selected from the Center region of ANKS1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.|
|Cellular Location||Cytoplasm Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note=The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). Isoform 6: Nucleus.|
|Tissue Location||Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines|
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Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.Isoform 3 can regulate global protein synthesis by altering nucleolar numbers (By similarity).Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Pei, D., et al. Genet Test Mol Biomarkers 14(3):433-438(2010)Wang, M., et al. Stat Biopharm Res 1(4):424-430(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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