|Other Names||Transcription factor CP2-like protein 1, CP2-related transcriptional repressor 1, CRTR-1, Transcription factor LBP-9, TFCP2L1, CRTR1, LBP9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13438b was selected from the C-term region of TFCP2L1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1.|
|Tissue Location||Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.|
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Provided below are standard protocols that you may find useful for product applications.
TFCP2L1 is a transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Modulates the placental expression of CYP11A1.
To, S., et al. PLoS ONE 5 (7), E11702 (2010) :Henderson, Y.C., et al. DNA Cell Biol. 27(2):71-79(2008)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Huang, N., et al. Mol. Endocrinol. 19(2):409-420(2005)Rodda, S., et al. J. Biol. Chem. 276(5):3324-3332(2001)
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