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JPH2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BR39 |
|---|---|
| Clone Names | 100405074 |
| Gene ID | 57158 |
|---|---|
| Other Names | Junctophilin-2, JP-2, Junctophilin type 2, JPH2, JP2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13445b was selected from the C-term region of JPH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | JPH2 (HGNC:14202) |
|---|---|
| Function | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). |
| Cellular Location | [Junctophilin-2]: Cell membrane {ECO:0000250|UniProtKB:Q9ET78}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ET78}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ET78}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands {ECO:0000250|UniProtKB:Q9ET78} |
| Tissue Location | Specifically expressed in skeletal muscle and heart. |
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Background
Junctional complexes between the plasma membrane andendoplasmic/sarcoplasmic reticulum are a common feature of allexcitable cell types and mediate cross talk between cell surfaceand intracellular ion channels. The protein encoded by this gene isa component of junctional complexes and is composed of a C-terminalhydrophobic segment spanning the endoplasmic/sarcoplasmic reticulummembrane and a remaining cytoplasmic domain that shows specificaffinity for the plasma membrane. This gene is a member of thejunctophilin gene family. Alternative splicing has been observed atthis locus and two variants encoding distinct isoforms aredescribed.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Woo, J.S., et al. Biochem. J. 427(1):125-134(2010)Yamazaki, D., et al. Pharmacol. Ther. 121(3):265-272(2009)Landstrom, A.P., et al. J. Mol. Cell. Cardiol. 42(6):1026-1035(2007)Matsushita, Y., et al. J. Hum. Genet. 52(6):543-548(2007)
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