|Other Names||Junctophilin-2, JP-2, Junctophilin type 2, JPH2, JP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13445b was selected from the C-term region of JPH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.|
|Cellular Location||Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands (By similarity).|
|Tissue Location||Specifically expressed in skeletal muscle and heart.|
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Provided below are standard protocols that you may find useful for product applications.
Junctional complexes between the plasma membrane andendoplasmic/sarcoplasmic reticulum are a common feature of allexcitable cell types and mediate cross talk between cell surfaceand intracellular ion channels. The protein encoded by this gene isa component of junctional complexes and is composed of a C-terminalhydrophobic segment spanning the endoplasmic/sarcoplasmic reticulummembrane and a remaining cytoplasmic domain that shows specificaffinity for the plasma membrane. This gene is a member of thejunctophilin gene family. Alternative splicing has been observed atthis locus and two variants encoding distinct isoforms aredescribed.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Woo, J.S., et al. Biochem. J. 427(1):125-134(2010)Yamazaki, D., et al. Pharmacol. Ther. 121(3):265-272(2009)Landstrom, A.P., et al. J. Mol. Cell. Cardiol. 42(6):1026-1035(2007)Matsushita, Y., et al. J. Hum. Genet. 52(6):543-548(2007)
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