|Other Names||Melanoma-associated antigen D4, MAGE-D4 antigen, MAGE-E1 antigen, MAGED4, KIAA1859, MAGED4A, MAGEE1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13447c was selected from the Center region of MAGED4B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1859, MAGED4A, MAGEE1|
|Function||May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.|
|Tissue Location||Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.|
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This gene is a member of the MAGED gene family. It isexpressed only in brain and ovary among normal tissues, and twotranscript variants of this gene are specifically expressed inglioma cells among cancer cells. This gene and the other MAGEDgenes are clustered on chromosome Xp11. Multiple alternativelyspliced transcript variants have been found for this gene, however,the full-length nature of some variants has not been defined.
Ito, S., et al. Lung Cancer 51(1):79-88(2006)Kawano, Y., et al. Gene 277 (1-2), 129-137 (2001) :Sasaki, M., et al. Cancer Res. 61(12):4809-4814(2001)
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