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NDFIP1 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9BT67
Clone Names 100405004
Peptide ID 100405004
Additional Information
Gene ID 80762
Other Names NEDD4 family-interacting protein 1, Breast cancer-associated protein SGA-1M, NEDD4 WW domain-binding protein 5, Putative MAPK-activating protein PM13, Putative NF-kappa-B-activating protein 164, Putative NFKB and MAPK-activating protein, NDFIP1, N4WBP5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13449c was selected from the Center region of NDFIP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms N4WBP5
Function Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.
Cellular Location Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Secreted Note=Detected in exosomes and secreted via the exosomal pathway
Tissue Location Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.
Research Areas
Citations (0)

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The protein encoded by this gene belongs to a small groupof evolutionarily conserved proteins with three transmembranedomains. It is a potential target for ubiquitination by the Nedd4family of proteins. This protein is thought to be part of a familyof integral Golgi membrane proteins.


Mund, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(25):11429-11434(2010)Howitt, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(36):15489-15494(2009)Rapley, E.A., et al. Nat. Genet. 41(7):807-810(2009)Mund, T., et al. EMBO Rep. 10(5):501-507(2009)Putz, U., et al. J. Biol. Chem. 283(47):32621-32627(2008)

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$ 80.00
Cat# BP13449c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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