|Other Names||Bromodomain-containing protein 7, 75 kDa bromodomain protein, Protein CELTIX-1, BRD7, BP75, CELTIX1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13451a was selected from the N-term region of BRD7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.|
|Cellular Location||Isoform 2: Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is a member of thebromodomain-containing protein family. The product of this gene hasbeen identified as a component of one form of the SWI/SNF chromatinremodeling complex, and as a protein which interacts with p53 andis required for p53-dependent oncogene-induced senescence whichprevents tumor growth. Pseudogenes have been described onchromosomes 2, 3, 6, 13 and 14. Alternative splicing results inmultiple transcript variants.
Burrows, A.E., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14280-14285(2010)Drost, J., et al. Nat. Cell Biol. 12(4):380-389(2010)Kikuchi, M., et al. Biochim. Biophys. Acta 1793(12):1828-1836(2009)Kaeser, M.D., et al. J. Biol. Chem. 283(47):32254-32263(2008)Liu, H., et al. BMC Mol. Biol. 9, 111 (2008) :
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