|Other Names||Hyaluronan and proteoglycan link protein 2, Brain link protein 1, HAPLN2, BRAL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13452b was selected from the C-term region of HAPLN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed only in adult brain.|
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HAPLN2 mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).
Sim, H., et al. J. Biol. Chem. 284(39):26547-26556(2009)Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009)Spicer, A.P., et al. J. Biol. Chem. 278(23):21083-21091(2003)Nomoto, H., et al. Acta Med. Okayama 56(1):25-29(2002)Oohashi, T., et al. Mol. Cell. Neurosci. 19(1):43-57(2002)
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