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C17orf95 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86XA0 |
|---|---|
| Clone Names | 100408259 |
| Gene ID | 124512 |
|---|---|
| Other Names | Methyltransferase-like protein 23, 211-, METTL23, C17orf95 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13464b was selected from the C-term region of C17orf95. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | METTL23 {ECO:0000303|PubMed:24501276, ECO:0000312|HGNC:HGNC:26988} |
|---|---|
| Function | Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity). |
| Cellular Location | Nucleus. Cytoplasm Note=Localizes in male and female zygote pronucleus and cytoplasm {ECO:0000250|UniProtKB:A2AA28} |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of the protein remains unknown.
References
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
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$ 277.78
Cat# BP13464b
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