TRIM39 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9HCM9 |
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Clone Names | 100408325 |
Gene ID | 56658 |
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Other Names | E3 ubiquitin-protein ligase TRIM39, 632-, RING finger protein 23, Testis-abundant finger protein, Tripartite motif-containing protein 39, TRIM39, RNF23, TFP |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13466c was selected from the Center region of TRIM39. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TRIM39 |
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Synonyms | RNF23, TFP |
Function | [Isoform 1]: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly- ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex- mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). |
Cellular Location | [Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. |
Tissue Location | Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The function of this protein has not beenidentified. This gene lies within the major histocompatibilitycomplex class I region on chromosome 6. Alternate splicing resultsin two transcript variants encoding different isoforms. [providedby RefSeq].
References
Kurata, R., et al. Biochem. Biophys. Res. Commun. 401(4):533-537(2010)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Lee, S.S., et al. Exp. Cell Res. 315(7):1313-1325(2009)Roberts, J.D. Jr., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 293 (4), L903-L912 (2007) :Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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