|Other Names||E3 ubiquitin-protein ligase TRIM39, 632-, RING finger protein 23, Testis-abundant finger protein, Tripartite motif-containing protein 39, TRIM39, RNF23, TFP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13466c was selected from the Center region of TRIM39. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.|
|Cellular Location||Cytoplasm, cytosol. Mitochondrion. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1|
|Tissue Location||Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The function of this protein has not beenidentified. This gene lies within the major histocompatibilitycomplex class I region on chromosome 6. Alternate splicing resultsin two transcript variants encoding different isoforms. [providedby RefSeq].
Kurata, R., et al. Biochem. Biophys. Res. Commun. 401(4):533-537(2010)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Lee, S.S., et al. Exp. Cell Res. 315(7):1313-1325(2009)Roberts, J.D. Jr., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 293 (4), L903-L912 (2007) :Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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