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GOPC Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HD26 |
|---|---|
| Clone Names | 100409022 |
| Gene ID | 57120 |
|---|---|
| Other Names | Golgi-associated PDZ and coiled-coil motif-containing protein, CFTR-associated ligand, Fused in glioblastoma, PDZ protein interacting specifically with TC10, PIST, GOPC, CAL, FIG |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13470b was selected from the C-term region of GOPC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GOPC (HGNC:17643) |
|---|---|
| Function | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). |
| Cellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein Synapse. Postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PIST is a PDZ domain-containing Golgi protein. PDZ domainscontain approximately 90 amino acids and bind the extreme Cterminus of proteins in a sequence-specific manner.[supplied byOMIM].
References
Cheng, J., et al. Mol. Biol. Cell 21(7):1178-1187(2010)Cushing, P.R., et al. Biochemistry 47(38):10084-10098(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Li, X., et al. Protein Sci. 15(9):2149-2158(2006)Ito, H., et al. Biochem. J. 397(3):389-398(2006)
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