|Other Names||Golgi-associated PDZ and coiled-coil motif-containing protein, CFTR-associated ligand, Fused in glioblastoma, PDZ protein interacting specifically with TC10, PIST, GOPC, CAL, FIG|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13470b was selected from the C-term region of GOPC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
PIST is a PDZ domain-containing Golgi protein. PDZ domainscontain approximately 90 amino acids and bind the extreme Cterminus of proteins in a sequence-specific manner.[supplied byOMIM].
Cheng, J., et al. Mol. Biol. Cell 21(7):1178-1187(2010)Cushing, P.R., et al. Biochemistry 47(38):10084-10098(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Li, X., et al. Protein Sci. 15(9):2149-2158(2006)Ito, H., et al. Biochem. J. 397(3):389-398(2006)
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