|Other Names||Serine/arginine-rich splicing factor 8, Pre-mRNA-splicing factor SRP46, Splicing factor SRp46, Splicing factor, arginine/serine-rich 2B, SRSF8, SFRS2B, SRP46|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13474a was selected from the N-term region of SFRS2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA alternative splicing.|
|Tissue Location||Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus|
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Provided below are standard protocols that you may find useful for product applications.
The SR (serine/arginine-rich) family contains a number ofphosphoproteins that function as essential and alternative splicingfactors. The SR family of proteins is characterized by the presenceof a ribonucleoprotein (RNP)-type RNA binding motif and acarboxyl-terminal arginine-serine-rich (RS) domain. The proteinencoded by this gene is a member of the SR family and functions asan essential splicing factor in vitro. This gene is thought to bean expressed PR264/SC35 retropseudogene.
Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010)Lareau, L.F., et al. Nature 446(7138):926-929(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Li, J., et al. Mol. Cell. Biol. 23(21):7437-7447(2003)Grottke, C., et al. Int. J. Cancer 88(4):535-546(2000)
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