|Other Names||Probable E3 ubiquitin-protein ligase DTX3, 632-, Protein deltex-3, Deltex3, RING finger protein 154, DTX3, RNF154|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13476a was selected from the N-term region of DTX3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.|
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Provided below are standard protocols that you may find useful for product applications.
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al.,2003 [PubMed 12670957]).
Chastagner, P., et al. EMBO Rep. 7(11):1147-1153(2006)Takeyama, K., et al. J. Biol. Chem. 278(24):21930-21937(2003)Kishi, N., et al. Int. J. Dev. Neurosci. 19(1):21-35(2001)Matsuno, K., et al. Development 121(8):2633-2644(1995)
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