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TLE6 Antibody (N-term ) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H808 |
|---|---|
| Clone Names | 100416084 |
| Gene ID | 79816 |
|---|---|
| Other Names | Transducin-like enhancer protein 6, TLE6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13485a was selected from the N-term region of TLE6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TLE6 |
|---|---|
| Function | Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9WVB3}. [Isoform 2]: Cytoplasm |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity).
References
Chen, P.C., et al. PLoS Genet. 4 (6), E1000092 (2008) :Dang, J., et al. Mol. Cell. Biol. 21(17):5935-5945(2001)
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