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PTPLA Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | B0YJ81 |
|---|---|
| Clone Names | 100416089 |
| Gene ID | 9200 |
|---|---|
| Other Names | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1, 3-hydroxyacyl-CoA dehydratase 1, HACD1, Cementum attachment protein, Protein-tyrosine phosphatase-like member A, PTPLA, HACD1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13486a was selected from the N-term region of PTPLA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HACD1 {ECO:0000303|PubMed:15164054, ECO:0000312|HGNC:HGNC:9639} |
|---|---|
| Function | [Isoform 1]: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
| Cellular Location | [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203). Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a characteristiccatalytic motif of the protein tyrosine phosphatases (PTPs) family.The PTP motif of this protein has the highly conserved arginineresidue replaced by a proline residue; thus it may represent adistinct class of PTPs. Members of the PTP family are known to besignaling molecules that regulate a variety of cellular processes.This gene was preferentially expressed in both adult and fetalheart. A much lower expression level was detected in skeletal andsmooth muscle tissues, and no expression was observed in othertissues. The tissue specific expression in the developing and adultheart suggests a role in regulating cardiac development anddifferentiation.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Liang, X., et al. Hum. Mutat. 30(3):463-471(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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