|Other Names||Vesicular glutamate transporter 3, VGluT3, Solute carrier family 17 member 8, SLC17A8, VGLUT3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13493a was selected from the N-term region of SLC17A8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome|
|Tissue Location||Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a vesicular glutamate transporter. Theencoded protein transports the neurotransmitter glutamate intosynaptic vesicles before it is released into the synaptic cleft.Mutations in this gene are the cause of autosomal-dominantnonsyndromic type 25 deafness. Alternate splicing results inmultiple transcript variants.
Ruel, J., et al. Am. J. Hum. Genet. 83(2):278-292(2008)Linke, N., et al. Histol. Histopathol. 23(8):979-986(2008)Almqvist, J., et al. Protein Sci. 16(9):1819-1829(2007)Gong, J., et al. Brain Res. 1082(1):73-85(2006)Seal, R.P., et al. Handb Exp Pharmacol 175, 137-150 (2006) :
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