|Other Names||POU domain, class 3, transcription factor 3, Brain-specific homeobox/POU domain protein 1, Brain-1, Brn-1, Octamer-binding protein 8, Oct-8, Octamer-binding transcription factor 8, OTF-8, POU3F3, BRN1, OTF8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13495c was selected from the Center region of POU3F3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
POU3F3 is a member of the class III POU family oftranscription factors (see POU3F1; MIM 602479) that are expressedin the central nervous system. The POU domain in these proteins isrequired for high affinity binding to octamer DNA sequences(summarized by Sumiyama et al., 1996 [PubMed 8703082]).[supplied byOMIM].
Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)Kuhlbrodt, K., et al. J. Biol. Chem. 273(26):16050-16057(1998)Sumiyama, K., et al. Mamm. Genome 9(2):180-181(1998)Malik, K.F., et al. Brain Res. Mol. Brain Res. 45(1):99-107(1997)Sumiyama, K., et al. J. Mol. Evol. 43(3):170-178(1996)
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