|Other Names||POU domain, class 3, transcription factor 3, Brain-specific homeobox/POU domain protein 1, Brain-1, Brn-1, Octamer-binding protein 8, Oct-8, Octamer-binding transcription factor 8, OTF-8, POU3F3, BRN1, OTF8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13495c was selected from the Center region of POU3F3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
POU3F3 is a member of the class III POU family oftranscription factors (see POU3F1; MIM 602479) that are expressedin the central nervous system. The POU domain in these proteins isrequired for high affinity binding to octamer DNA sequences(summarized by Sumiyama et al., 1996 [PubMed 8703082]).[supplied byOMIM].
Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)Kuhlbrodt, K., et al. J. Biol. Chem. 273(26):16050-16057(1998)Sumiyama, K., et al. Mamm. Genome 9(2):180-181(1998)Malik, K.F., et al. Brain Res. Mol. Brain Res. 45(1):99-107(1997)Sumiyama, K., et al. J. Mol. Evol. 43(3):170-178(1996)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.