|Other Names||Butyrophilin subfamily 3 member A1, CD277, BTN3A1, BTF5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13499b was selected from the C-term region of BTN3A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.|
|Cellular Location||Cell membrane; Single- pass type I membrane protein|
|Tissue Location||Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The butyrophilin (BTN) genes are a group of majorhistocompatibility complex (MHC)-associated genes that encode typeI membrane proteins with 2 extracellular immunoglobulin (Ig)domains and an intracellular B30.2 (PRYSPRY) domain. Threesubfamilies of human BTN genes are located in the MHC class Iregion: the single-copy BTN1A1 gene (MIM 601610) and the BTN2(e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, whichhave undergone tandem duplication, resulting in 3 copies of each(summary by Smith et al., 2010 [PubMed 20208008]).[supplied byOMIM].
Smith, I.A., et al. J. Immunol. 184(7):3514-3525(2010)Shi, J., et al. Nature 460(7256):753-757(2009)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Rhodes, D.A., et al. Genomics 71(3):351-362(2001)
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