|Other Names||Sodium-dependent neutral amino acid transporter SLC6A17, Sodium-dependent neurotransmitter transporter NTT4, Solute carrier family 6 member 17, SLC6A17, NTT4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13508b was selected from the C-term region of SLC6A17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The SLC6 family of proteins, which includes SLC6A17, actsas specific transporters for neurotransmitters, amino acids, andosmolytes like betaine, taurine, and creatine. SLC6 proteins aresodium cotransporters that derive the energy for solute transportfrom the electrochemical gradient for sodium ions (Hoglund et al.,2005 [PubMed 16125675]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zaia, K.A., et al. J. Biol. Chem. 284(13):8439-8448(2009)Hoglund, P.J., et al. Biochem. Biophys. Res. Commun. 336(1):175-189(2005)
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