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SLC6A17 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H1V8 |
|---|---|
| Clone Names | 100416200 |
| Gene ID | 388662 |
|---|---|
| Other Names | Sodium-dependent neutral amino acid transporter SLC6A17, Sodium-dependent neurotransmitter transporter NTT4, Solute carrier family 6 member 17, SLC6A17, NTT4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13508b was selected from the C-term region of SLC6A17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC6A17 {ECO:0000250|UniProtKB:P31662, ECO:0000312|HGNC:HGNC:31399} |
|---|---|
| Function | Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride- independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P31662}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31662}. Postsynapse {ECO:0000250|UniProtKB:Q8BJI1}. Presynapse {ECO:0000250|UniProtKB:Q8BJI1}. Note=Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals. {ECO:0000250|UniProtKB:Q8BJI1} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The SLC6 family of proteins, which includes SLC6A17, actsas specific transporters for neurotransmitters, amino acids, andosmolytes like betaine, taurine, and creatine. SLC6 proteins aresodium cotransporters that derive the energy for solute transportfrom the electrochemical gradient for sodium ions (Hoglund et al.,2005 [PubMed 16125675]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zaia, K.A., et al. J. Biol. Chem. 284(13):8439-8448(2009)Hoglund, P.J., et al. Biochem. Biophys. Res. Commun. 336(1):175-189(2005)
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