|Other Names||Cas scaffolding protein family member 4, HEF-like protein, HEF1-EFS-p130Cas-like protein, HEPL, CASS4, C20orf32, HEFL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13515b was selected from the C-term region of CASS4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Docking protein that plays a role in tyrosine kinase- based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, focal adhesion|
|Tissue Location||Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Possible docking protein which may play a role for tyrosine-kinase-based signaling related to cell adhesion. Regulates FAK activity, focal adhesion integrity, and cell spreading.
Singh, M.K., et al. Mol. Biol. Cell 19(4):1627-1636(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Deloukas, P., et al. Nature 414(6866):865-871(2001)
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