MORC1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86VD1 |
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Clone Names | 100422074 |
Gene ID | 27136 |
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Other Names | MORC family CW-type zinc finger protein 1, Cancer/testis antigen 33, CT33, MORC1 {ECO:0000312|EMBL:AAH503071} |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13528b was selected from the C-term region of MORC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MORC1 {ECO:0000312|EMBL:AAH50307.1} |
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Function | Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9WVL5}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the human homolog of mouse morc and likethe mouse protein it is testis-specific. Mouse studies support atestis-specific function since only male knockout mice areinfertile; infertility is the only apparent defect. These studiesfurther support a role for this protein early in spermatogenesis,possibly by affecting entry into apoptosis because testis fromknockout mice show greatly increased numbers of apoptotic cells.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Inoue, N., et al. Cytogenet. Cell Genet. 90 (1-2), 123-125 (2000) :Inoue, N., et al. Hum. Mol. Genet. 8(7):1201-1207(1999)
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