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NLRP6 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P59044
Clone Names 100422080
Peptide ID 100422080
Additional Information
Gene ID 171389
Other Names NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13529a was selected from the N-term region of NLRP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP6
Synonyms NALP6, PYPAF5
Function May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity).
Cellular Location Cytoplasm. Cell membrane. Nucleus membrane
Tissue Location Highly expressed in granulocytes. Detected at much lower levels in T-cells
Research Areas
Citations (0)

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NALPs are cytoplasmic proteins that form a subfamilywithin the larger CATERPILLER protein family. Most short NALPs,such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),and a C-terminal leucine-rich repeat (LRR) region. The long NALP,NALP1 (MIM 606636), also has a C-terminal extension containing afunction to find domain (FIIND) and a caspase recruitment domain(CARD). NALPs are implicated in the activation of proinflammatorycaspases (e.g., CASP1; MIM 147678) via their involvement inmultiprotein complexes called inflammasomes (Tschopp et al., 2003[PubMed 12563287]).


Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Albrecht, M., et al. FEBS Lett. 538 (1-3), 173-177 (2003) :Tschopp, J., et al. Nat. Rev. Mol. Cell Biol. 4(2):95-104(2003)Grenier, J.M., et al. FEBS Lett. 530 (1-3), 73-78 (2002) :

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$ 80.00
Cat# BP13529a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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