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NLRP6 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P59044
Clone Names 100422080
Peptide ID 100422080
Additional Information
Gene ID 171389
Other Names NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13529a was selected from the N-term region of NLRP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP6
Synonyms NALP6, PYPAF5
Function As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1- catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome- dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity).
Cellular Location Cytoplasm. Inflammasome. Cell membrane {ECO:0000250|UniProtKB:Q63035}. Nucleus membrane {ECO:0000250|UniProtKB:Q63035}
Tissue Location Expressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Expressed in colonic myofibroblasts (at protein level) (PubMed:21593405).
Research Areas
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Background

NALPs are cytoplasmic proteins that form a subfamilywithin the larger CATERPILLER protein family. Most short NALPs,such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),and a C-terminal leucine-rich repeat (LRR) region. The long NALP,NALP1 (MIM 606636), also has a C-terminal extension containing afunction to find domain (FIIND) and a caspase recruitment domain(CARD). NALPs are implicated in the activation of proinflammatorycaspases (e.g., CASP1; MIM 147678) via their involvement inmultiprotein complexes called inflammasomes (Tschopp et al., 2003[PubMed 12563287]).

References

Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Albrecht, M., et al. FEBS Lett. 538 (1-3), 173-177 (2003) :Tschopp, J., et al. Nat. Rev. Mol. Cell Biol. 4(2):95-104(2003)Grenier, J.M., et al. FEBS Lett. 530 (1-3), 73-78 (2002) :

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$ 80.00
Cat# BP13529a
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